At Sooam Biotech Research Foundation, canines are one of the highest priority subjects in our research. With years of constant and steady progress, new ways to explore the mechanisms of metabolic, cardiovascular, and neurodegenerative diseases have become paramount, serving both research and pharmaceutical purposes. In particular, type 1 & 2 diabetes mellitus and Alzheimer's disease dog models are being studied at Sooam.

 

Sooam hopes to help both humans and animals through canine transgenic research. Humans can be helped by creating appropriate animal models that can mimic the pathophysiology of many diseases observed in humans. Animals can be helped by eliminating unnecessary pain they have to go through during physical and chemical disease inducement procedures.

 

To date, Sooam has delivered over 200 cloned dogs, among which 28 are type 2 diabetes transgenic disease model dogs and 15 are Alzheimer's transgenic disease model dogs.

 

(Left) Transgenic Alzheimer's disease model, and (Right) GFP (green fluorescence protein) expression in nails, toes, and white hairs.

 

 

Publications

 

I.H. Hong, Y.W. Jeong, T. Shin, S.H. Hyun, J.K. Park ,M.R. Ki, S.Y. Han, S.I. Par, J.H.Lee, E.M. Lee, A.Y. Kim, S.Y. You, W.S.Hwang, and K.S. Jeong Morphological Abnormalities, Impaired Fetal Development and Decrease in Myostatin Expression Folowing Somatic Cell Nuclear Transfer in Dogs. Molecular Reproduction & Development (2011)

 

M.Sh. Hossein, Y.W. Jeong, S.W. Park, J.J. Kim, E. Lee, K.H. Ko, P. Hyuk, S.S. Hoon, Y.W. Kim, S.H. Hyun, T. Shin, and W.S. Hwang. Birth of Beagle dogs by somatic nuclear transfer. Animal Reproduction Science 114 (2009): 404-414

 

S.Kim, S.W. Park, M.S. Hossein, Y.W. Jeong, J.J. Kim, E. Lee, Y.W. Kim, S.H. Hyun, T. Shin, and W.S. Hwang. Production of Cloned Dogs by Decreasing the Interval Between Fusion and Activation During Somatic Cell Nuclear Transfer. Molecular Reproduction & Development 76 (2009): 483-489

 

M.S. Hossein, Y.W. Jeong, S.W. Park, J.J. Kim, E. Lee, K.H. Ko, H.S. Kim, Y. W. Kim, S.H. Hyun, T. Shin, L. Hawthorne, and W.S. Hwang. Cloning Missy: Obtaining Multiple Offspring of a Specific Canine Genotype by Somatic Cell Nuclear Transfer. Cloning and Stem Cells 11(2009):123-30

 

E. Lee, J.H. Kim, S.M. Park, Y.I. Jeong, J.Y. Lee, S.W. Park, J. Choi, H.S. Kim, Y.W. Jeong, S. Kim, S.H. Hyun, and W.S. Hwang. The analysis of chromatin remodeling and the staining for DNA methylation and histone acetylation do not provide definitive indicators of the developmental ability of inter-species cloned embryos. Animal Reproduction Science 105 (2008): 438-450